O2 content: Decreased
PaO2: Normal
SaO2: Decreased(Higher affinity of CO for Hb than O2)
Left shifts O2 dissociation curve
Inhibits Cytochrome oxidase
Causes:
Car exhaust
Space heaters
Smoke inhalation in fires(house fires-also have cyanide poisoning)
Wood stoves
Methylene Chloride
S/S:
Headache
Cherry red color of CO-Hb, masks cyanosis.
Long term: Necrosis of Globus Pallidus leading to Parkinson-like findings.
Rx:
100% O2
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